This is a case of a 59 year-old female was seen due to pain and purulentdischarge on the right mandible. Patient is a diagnosed case of multiple myeloma three years prior to admission who was treated with melphalan, prednisone, zolendronic acid, and has undergone radiotherapy for 25 sessions. Panoramic radiograph of the mandibles showed radioluscency at the body of mandible suggestive of an osteonecrotic process. After discovering this, zolendronic acid was discontinued and sequestrectomy and hyperbaric oxygen was done as advised by the maxillofacial surgeon.